Novel, Efficacious Antibiotics Produced by Bacillus subtilis DB9011

Antibiotic activities of the Bacillus subtilis DB9011 culture supernatant extracts against 52 pathogenic microbes were screened by measuring the zone of growth inhibition of the pathogens under a sterile paper disc loaded with the supernatant extract. The first scientific evidence for the effectiveness of the DB9011 culture extract against Porphyromonas gingivalis, Clostridium difficile, Propionibacterium acnes, and Legionella pneumophila is presented here. These organisms are causative pathogens of periodontal disease, Clostridium difficile-associated colitis, acne, and pneumonia, respectively. The findings from the present study will contribute to the development of more efficacious and safer pharmacotherapeutic agents for these diseases.